WebSep 14, 2024 · The transmembrane 4 superfamily (tetraspanins [TSPANs]) is a mediator of tumor microenvironment interactions and metastasis in solid tumors. 18,19 TSPANs promote these effects through surface interactions with a variety of adhesion molecules like integrins. 20-23 Evidence of the role of TSPANs in regulating microenvironmental … Web(encoded by Csnk1a1) in skin physiology, we crossed mice harboring floxed Csnk1a1 with mice expressing K14–Cre–ERT2 to generate mice in which tamoxifen induces the deletion of Csnk1a1 exclusively in keratinocytes [single-knockout (SKO) mice]. As expected, CK1α loss was accompanied by β-catenin and p53 stabilization, with the
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Web025398 B6.129(Cg)- Csnk1a1 tm1.1Ybn /J These CsnK1a1 fl floxed mice allow Cre recombinase-inducible knockout of casein kinase Ia (CKIα) for studying multiple cellular processes (Wnt pathway, cell cycle regulation, DNA damage response, KRAS-MEK-ERK mitogenic signaling, β-catenin-destruction complex) in cancer and senescence … WebJul 7, 2015 · We next sought to use a conditional knockout mouse model to determine whether haploinsufficiency for Csnk1a1 sensitizes cells to lenalidomide treatment. 15 In initial experiments, we found that lenalidomide did not decrease CK1α protein levels in mouse Ba/F3 cells, primary murine leukemia cells, or mice treated in vivo (Fig. 4a,b, … can of rose wine
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WebPhenotype data for mouse gene Csnk1a1. Discover Csnk1a1's significant phenotypes, expression, images, histopathology and more. Data for gene Csnk1a1 is all freely available for download. ... Phenotyping is currently not planned for a knockout strain of this gene. Gene Summary. Name: casein kinase 1, alpha 1. Synonyms: 5430427P18Rik, CK1a ... WebHere we report the discovery of a viable therapeutic target, nonmuscle myosin II (NMIIB), a molecular motor that supports memory by directly driving synaptic actin polymerization. WebApr 12, 2024 · To determine whether H3.3K27M is required for tumor maintenance in vivo, we performed orthotopic transplantation of patient cells or H3-3A K27M knockout cells into immunocompromised nonobese diabetic, severe combined immunodeficiency disease, gamma (NSG) mice at postnatal day 3 (P3) . We used the SU-DIPG-XIII line for this … can of salmon