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WebJan 30, 2024 · Most OTC sleep aids induce sleep using antihistamines, but you'll also find popular supplements like melatonin and valerian in the pharmacy aisles. Here's what you can expect from each type:... WebJun 8, 2024 · Sleep aids: The options. Sleep aids available without a prescription are widely available. Common choices and the potential side effects include: Diphenhydramine (Benadryl). Diphenhydramine is a sedating antihistamine. Side effects might include daytime drowsiness, dry mouth, constipation and urinary retention. Doxylamine (Unisom).

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