Harmonin
WebFeb 8, 2010 · The harmonin/Sans complex may serve as a platform to interact with many other proteins related to the development of hearing and visual cells in mammals via a … WebMar 29, 2024 · Harmonin can adopt two different structural states, 'open' and 'closed', as a result of the self-interaction between its domains. In summary, our studies provide novel insight into the functional relationship between USH1 and USH2 proteins in the cochlea and the retina as well as the disease mechanisms underlying USH1 and USH2.
Harmonin
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WebNov 13, 2007 · Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in … WebMar 1, 2003 · These results demonstrate that SANS underlies USH1G. The SANS protein contains three ankyrin domains and a sterile alpha motif, and its C-terminal tripeptide presents a class I PDZ-binding motif. We showed, by means of co-transfection experiments, that SANS associates with harmonin, a PDZ domain-containing protein responsible for …
WebHeadquartered in Brighton, Michigan with stocking offices in Cleveland, Ohio and Grand Rapids, Michigan, H.H.Barnum is the leader in products, solutions and controls for … WebMay 5, 2009 · Here we show that the PDZ-domain protein harmonin is a component of the upper tip-link density (UTLD), where CDH23 inserts into the stereociliary membrane. …
WebAug 23, 2024 · Harmonin perhaps contributes to the linkage of the OLM junction complexes to the actin cytoskeleton. This is supported by the observed co-localization and binding of harmonin to the actin-binding protein filamin A, which has been described as an important component of the actin cytoskeleton in barrier-forming cell–cell adhesion complexes ... WebHormodin 3 is prepared specially for propagating the more difficult to root varieties, including many of the evergreens and dormant leafless cuttings. Hormodin is a root inducing plant …
WebApr 13, 2010 · Well, I mentioned that I wanted to choose a protein with some connection to music. After doing a bit of browsing around on Google Scholar, I came across the structural protein harmonin. This protein helps to maintain the structure of stereocillia, the small hairs in the inner ear that detect sound waves and ultimately make hearing possible.
WebJun 27, 2024 · Impact of harmonin topology on the interaction with binding partners. The closed conformation of harmonin-a1 resembles the auto-inhibited conformation of another PDZ domain-containing scaffold protein of the hair bundle, NHERF-1, in which the C-terminal PBM interacts with the first and second PDZ domains of the protein . We, thus, … cdb file ansysWebOct 19, 2024 · Harmonin homology domain-mediated interaction of RTEL1 helicase with RPA and DNA provides mechanistic insight into its role in DNA repair. Niranjan Kumar, … buteo swainsoniWebSep 28, 2012 · Harmonin has three isoforms: a, b, and c (Fig. 1 A) (13).Harmonin-b plays the most important role in cadherin23 anchorage (14, 15).It contains a NTD and three PDZ domains together with two coiled-coil regions and a proline-serine-threonine-rich (PST) region situated between PDZ2 and PDZ3. cdb fd interest ratesWebHarmonin is a protein that in humans is encoded by the USH1C gene. It is expressed in sensory cells of the inner ear and retina, where it plays a role in hearing, balance, and … cdb foodWebHarmonin is a submembranous protein containing PDZ domains that is encoded by the gene responsible for Usher syndrome type 1C (USH1C), a disease characterised by congenital pro-found deafness and vestibular dysfunction and delayed onset retinopathy leading to blindness. Harmonin consists of three classes of isoforms [9, 48]. Harmonin … buteo start labelbuteo translationWebThis product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility. - Improved sensitivity … bute park attack